Ravensthorpe Morrisons is to close, the supermarket chain has announced.
It is one of 10 loss-making stores that will shut this year, with the loss of 409 jobs.
Morrisons took over the Huddersfield Road store from Netto in 2011.
A Morrisons spokesperson said: “We have looked extremely carefully at whether the stores can be turned around but unfortunately we cannot see a way of making them viable. We are therefore proposing their closure.
“We are consulting with colleagues and unions to reduce the risk of redundancies and we are looking at ways of redeploying colleagues around our business.”
Morrisons announced the departure of its chief executive Dalton Philips this week.
Incoming chairman Andy Higginson said that the bulk of the job cuts will be in the North.